• Introduction The carnitine choline acyltransferase family is

  2021-01-15

  

  Introduction The carnitine/choline acyltransferase family is a family of enzymes that play diverse roles, ranging from (the regulation of) Alamethicin and fuel metabolism in mitochondria and peroxisomes to the generation of the neurotransmitter acetylcholine. In mammals, this family consists of se

• After the policy of the current British Commonwealth countri

  2021-01-15

  

  After 1915, the policy of the (current) British Commonwealth countries (including Britain, Canada, Australia, India, New Zealand and South Africa) regarding the dead, was to ensure that as far as possible, whether identified or not, all recovered bodies would be given individual graves, with standar

• The idea of boron based pro estrogens has

  2021-01-15

  

  The idea of boron-based pro-estrogens has been utilized before; in previous studies, the selective estrogen receptor modulators (SERMs) tamoxifen and endoxifen have been masked as boronate esters.13, 14, 15 Tamoxifen and endoxifen both target ERα as therapies for breast cancer. The previous work foc

• Previous studies demonstrated that cPLA translocates to the

  2021-01-14

  

  Previous studies demonstrated that cPLA2α translocates to the phagosomal membrane during macrophage phagocytosis through mechanisms that, in humans, involve phosphorylation of the enzyme by c-Jun N-terminal kinases and membrane association via the cationic cluster of four lysine residues present at

• Atovaquone In summary we investigated the fluoride sensitivi

  2021-01-14

  

  In summary, we investigated the fluoride sensitivity of different S. mutans strains in terms of enolase activity. Lower enolase activity was not always associated with lower S. mutans growth in cultures with NaF. Gene analysis showed that UA130 and NCH105 both have enolase point mutations. Unique am

• br Acknowledgements The present study

  2021-01-14

  

  Acknowledgements The present study was supported by the Medical Science and Technology Program of Zhejiang Province2014KYA228 (Zhijun Zhou), 2016KYA195 (Jie Li) and 2017KY714 (Qingqing Xia); Zhejiang Provincial Natural Science Foundation of ChinaQ17H120001 (Jie Li); and Scientific Research Projec

• First KEGG and GO annotation were conducted for

  2021-01-14

  

  First, KEGG and GO annotation were conducted for these 1251 genes. Then, combining the pathway enrichment analysis, we explored how these genes could function in breast cancer. We discovered that neuroactive ligand-receptor interaction was the most enriched pathway, which comprised numerous G protei

• br Results To understand how Rad

  2021-01-14

  

  Results To understand how Rad53 functions to maintain replisome integrity, we first analyzed newly synthesized leading- and lagging-strand DNA in wild-type (WT) and rad53-1 mutant cells using BrdU-IP-ssSeq, a method that detects synthesis of both leading and lagging strands (Yu et al., 2014). Bri

• DASA-58 synthesis br Results br Discussion Thus the biochemi

  2021-01-14

  

  Results Discussion Thus, the biochemical and structural studies of six Maf proteins from different organisms have revealed two subfamilies of new enzymes with the metal-dependent nucleoside triphosphate pyrophosphatase activity against both canonical and noncanonical pyrimidine nucleotides (Yh

• Air trapping at the small airways is

  2021-01-14

  

  Air-trapping at the small airways is related to severe ahr pathway (Bjermer, 2014), and acute exacerbation (Mahut et al., 2010). Although asthma patients are generally treated with inhaled corticosteroid (ICS) or with ICS and long-acting β2 agonist (LABA), the efficacy of such treatment depends on

• The objective of the present study

  2021-01-14

  

  The objective of the present study was to investigate the role of the CRF system in the neuroadaptations associated with nicotine dependence. To this aim, the regulation of the gene expression of CRF and its receptors was assessed in Sirolimus regions belonging to the reward pathway using a model o

• br Activatable MRI probes MRI

  2021-01-14

  

  Activatable MRI probes MRI is commonly used in clinics around the world and has the advantages of outstanding tissue-penetration depth and extremely high spatial resolution for in vivo imaging [33]. MRI has relatively poor sensitivity and usually requires Berberine hydrochloride agents to enhanc

• Gadodiamide A growing body of data indicates that endothelia

  2021-01-13

  

  A growing body of data indicates that endothelial NOS (eNOS) is a rate-limiting enzyme for the synthesis of nitric oxide (NO), its downstream Gadodiamide molecule. High pathological concentrations of NO produced from inducible NO synthase (iNOS) induce apoptosis, whereas a reduction in the concentr

• The importance of EBI for B cell

  2021-01-13

  

  The importance of EBI2 for B cell function was first suggested by the dramatic upregulation of this receptor in EBV-transformed B cells and further inferred from its regulation in activated and GC B cells (Birkenbach et al., 1993, Glynne et al., 2000, Shaffer et al., 2000). An involvement of EBI2 in

• Introduction Determining how genes function together as biol

  2021-01-13

  

  Introduction Determining how genes function together as biological systems is a defining challenge of the genomic era. While genome sequences reveal the DNA blueprint of organisms, deciphering how this blueprint leads to biological function is challenging due in large part to the complexity of prot

15740 records 696/1050 page Previous Next First page 上5页 696697698699700 下5页 Last page