• br Criteria for ER targeted fluorescent probes br Survey

  2021-01-23

  

  Criteria for ER-targeted fluorescent probes Survey of fluorescent probes Proposed approach to high affinity fluorescent steroidal ER probes Our proposed approach to the development of a new generation of fluorescent estrogen receptor imaging agents employs many of the elements present in th

• Then the mechanisms responsible for

  2021-01-23

  

  Then the mechanisms responsible for BPA induced up regulation of ERRγ were further investigated. Recent studies indicated that Akt and MPAK can modulate the protein levels and transcriptional activities of ERRγ (Heckler et al., 2014, Sun et al., 2014). Previous studies also indicated that BPA can ac

• Enzyme selectivity of many enzymes like galactosidases acyla

  2021-01-23

  

  Enzyme selectivity of many Ac-IEPD-AFC receptor like β-galactosidases, acylases, epoxyhydrolases, lipases, etc. has also been modulated by using different immobilization techniques. It can result in the selection of optimal biocatalyst for different processes. This has many advantages over strategie

• The contribution of local ETA

  2021-01-23

  

  The contribution of local ETA and ETB receptors towards heat hyperalgesia induced by inoculation of XC tumor dopamine antagonist drugs in the paw of mice has been demonstrated by Baamonde and colleagues (Baamonde et al., 2004). Furthermore, using neuropathic and inflammatory nociception models, sev

• It is particularly notable that CYP D appears to be

  2021-01-23

  

  It is particularly notable that CYP2D6 appears to be the most stable of the major CYP450 a66 in its expression over time in vitro and appears to be least affected by culture conditions and sample to sample variability (i.e., CYP2D6 expression is remarkably consistent over time and between individua

• To elucidate whether the impact

  2021-01-23

  

  To elucidate whether the impact of hypoxia on EGFR expression is cell context specific or culturing density dependent, we chose the following cancer glycogen phosphorylase synthesis driven by EGFR and evaluated the EGFR expression after hypoxia treatment at different culturing density: a highly agg

• As an endogenous negative modulator

  2021-01-23

  

  As an endogenous negative modulator, CRBN inhibits AMPK’s activation (phosphorylation of Thr172) by directly binding to the α-subunit of AMPK, disrupting γ-subunit recruitment to the AMPK complex (Lee et al., 2011, Lee et al., 2013). In our study, we did not focus on AMPK activation, since only a si

• For reductive amination by L AmDH the term related to

  2021-01-22

  

  For reductive amination by L-AmDH, the term related to the enzyme-ammonia complex is excluded rather than the enzyme-pentanone term (Table 1). If this were an ordered mechanism, this would imply ammonia binds second, after NADH and before 2-pentanone. However, a large KM,NH4 value renders ammonia bi

• br NADH and NADPH Turnover and the Putative Role of

  2021-01-22

  

  NADH and NADPH Turnover and the Putative Role of Alternative NAD(P)H Dehydrogenases Still very little is known about the metabolic function of external and internal alternative NADH:UQ oxidoreductases, and almost nothing is known about the mechanisms underlying their metabolic regulation, especia

• It has been reported that CysLT receptors negatively

  2021-01-22

  

  It has been reported that CysLT2 receptors negatively regulate CysLT1 receptor-mediated response in allergic airway inflammation in mice. Knockdown of CysLT2 receptors augmented CysLT1 receptor-mediated mast cell proliferation [31] and eosinophilic airway inflammation induced by antigen challenge in

• In rats exposed to day of nicotine

  2021-01-22

  

  In rats exposed to 1 day of nicotine withdrawal (24 h after the last nicotine administration) we expected a decrease of general locomotor activity and a decrease of global striatal dopamine release, which were assessed in a previous study following 14 days of nicotine exposure and 24 h of nicotine w

• Taken together our results demonstrate that

  2021-01-22

  

  Taken together, our results demonstrate that the changes of striatal dopamine release and locomotor activity observed following chronic nicotine treatment and consequent acute withdrawal are mediated by CRF1, but not CRF2. Previous studies have already indicated that blocking CRF1 would prevent some

• br Conclusions br Acknowledgements This work was

  2021-01-22

  

  Conclusions Acknowledgements This work was supported by funding from the Natural Sciences and Engineering Research Council of Canada (RGPIN-2017-06346 to JB), National Institute of Child Health and Human Development (5R01HD083930-02 to JB), and the National Institute of Biomedical Imaging and

• Mass spectrometry has previously been

  2021-01-22

  

  Mass spectrometry has previously been used to examine the presence of Hyp in recombinant collagen, using hydrolysates to identify the individual imino acid, equivalent to an amino cox inhibitor analysis [33], and also by analysis of mass changes to tryptic peptides [34]. The present study, however,

• In human neuroblastoma SH SY Y

  2021-01-22

  

  In human neuroblastoma SH-SY5Y TG003 australia and in lymphoma Jurkat cells, Yamanaka et al. [56] showed that exogenously added 24(S)-hydroxycholesterol could be efficiently esterified by ACAT1. These results suggest that both ACAT1 and ACAT2 can control the oxysterol levels by directly esterifying

15743 records 691/1050 page Previous Next First page 上5页 691692693694695 下5页 Last page