• br Effects of culture conditions on drug induced

  2021-04-20

  

  Effects of culture conditions on drug-induced gene Metformin in primary human hepatocytes Past progress in elucidating the optimal conditions for the long-term cultivation of rodent hepatocytes has helped define some of the key components in the matrix and medium environment that are most critic

• Further indirect evidence supporting an important role of DP

  2021-04-20

  

  Further indirect evidence supporting an important role of DPP-4 in the modulating the actions of both incretins comes from the observations that analogues of GLP-1 and GIP, modified to be resistant to DPP-4 cleavage, were subsequently shown to have greater metabolic stability in vivo which was assoc

• br Introduction Type Diabetes mellitus T

  2021-04-20

  

  Introduction Type 2 Diabetes mellitus (T2DM) is a metabolic disorder that raises blood glucose level for a prolonged time. T2DM is associated with acute complications like ketoacidosis, hyposmolar coma, chronic complications include heart disease, stroke, kidney failure, foot ulcers and damage to

• Pol is responsible for the bulk of

  2021-04-20

  

  Pol ε is responsible for the bulk of leading-strand synthesis in vivo (Daigaku et al., 2015, Nick McElhinny et al., 2008, Pursell et al., 2007) and physically associates with CMG (Langston et al., 2014, Sengupta et al., 2013, Sun et al., 2015, Zhou et al., 2017). Furthermore, leading-strand synthesi

• br Discussion Although DNA has

  2021-04-20

  

  Discussion Although DNA has a limited chemical stability it has long been known that DNA in blood stains may remain relative stable for weeks, months, or even years at ambient temperature,1, 2, 3, 4, 5, 6 and samples (e.g., reference samples) that have been transferred to a matrix, e.g., FTA® pap

• The two isoforms LDH A and

  2021-04-20

  

  The two isoforms LDH-A and LDH-B catalyze the same reaction, conversion of pyruvate to lactate at the end of glycolysis. LDH-A is expressed in the liver. Humans with a hereditary deficiency of the A or B LDH isoforms are free of symptoms, except for muscle rigidity and myoglobinuria following strenu

• Intriguingly our laboratory has shown that

  2021-04-20

  

  Intriguingly, our laboratory has shown that the I638F kinase domain mutant, unlike the L63V and G505 mutants, is incapable of receptor autophosphorylation and activation of its downstream effector SHP-2 when exposed to collagen stimulation. These data indicate that I638F is a loss of function mutati

• br Introduction The allergic response is a complex process i

  2021-04-20

  

  Introduction The allergic response is a complex process involving the interaction of several mediators; among these, cysteinyl leukotrienes (CysLTs) represent one of the most important actors in the pathogenesis of airway allergic diseases such as allergic rhinitis and asthma [1]. Pharmacological

• In contrast to chordates authentic

  2021-04-20

  

  In contrast to chordates, authentic chemokine and receptor orthologues can be found in the agnathan fishes (Bajoghli, 2013, Kuroda et al., 2003, Nomiyama et al., 2011, Nomiyama et al., 2013); sea lamprey has at least five chemokine receptor genes, one CXCR4 (Ensembl Acc. No.: ENSPMAP00000007678) (Ku

• Cryoprotectant equilibration and the response to ice

  2021-04-19

  

  Cryoprotectant equilibration and the response to ice concentrated media are the two facets of cellular cryobiological protocols most commonly covered by mathematical modeling. In these models, DASA-58 are typically assumed to have uniform, spatially independent extracellular concentrations and tempe

• The current study showed that

  2021-04-19

  

  The current study showed that the tested nonselective COX inhibitors potentiated the neuronal (EFS) and endothelial (ACh)-dependent relaxation of rat corpus cavernosum. Indomethacin was the most effective among them in potentiating EFS-induced relaxation. Diclofenac was the most effective in potenti

• Due to its several industrial applications the recombinant p

  2021-04-19

  

  Due to its several industrial applications, the recombinant production of collagen and all its derivatives as gelatins has been pursued for many years in different biological systems as mammalian donepezil hcl (Toman et al., 1999), tobacco plants (Ruggiero et al., 2000), silkworms (Tomita et al., 2

• There is a considerable molecular genetic heterogeneity with

  2021-04-19

  

  There is a considerable molecular genetic heterogeneity within ES/PNET. As mentioned above, either or can rearrange with in these gene fusions. Furthermore, for either gene fusion, additional heterogeneity stems from the location of the genomic breakpoints of the translocation, resulting in diffe

• In particular EphB has been one

  2021-04-19

  

  In particular, EphB4 has been one of the most studied receptor of the Eph family: inhibition of EphB4 expression using interfering-RNA or antisense oligonucleotides inhibited proliferation, survival and invasion of PC3 prostate cancer Pyrintegrin receptor in vitro and in vivo. Inhibition of EphB4 s

• br Funding This work was supported by intramural funding

  2021-04-19

  

  Funding This work was supported by intramural funding of the Department of Internal Medicine I-Cardiology, University Hospital Aachen, RWTH Aachen. Acknowledgments Introduction Cyclic adenosine monophosphate (cAMP) is a central second messenger that controls a plethora of vital functions.

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