• br O GlcNAcase Human OGA

  2021-06-02

  

  O-GlcNAcase Human OGA is a multidomain protein with an N-terminal domain similar to glycoside hydrolase family 84 (GH84) enzymes, a stalk domain, a C-terminal pseudo histone acetyltransferase (HAT) domain, and several low-complexity regions (Figure 1f) [43]. A splice variant that lacks the HAT do

• The applications of fungal enzymes in paper industry involve

  2021-06-02

  

  The applications of fungal enzymes in paper industry involve biobleaching of pulp, pulp de-inking, degradation of dissolved and suspended organic compounds in concentrated effluents of mills and enhanced fibrillation. Enzymes usage is encouraged in paper industry in order to reduce the use of chemic

• br Conflict of interest br Introduction

  2021-06-01

  

  Conflict of interest Introduction Endothelin receptors are members of the superfamily of G-protein-coupled receptors (GPCRs) and central regulators of vascular tension and other physiological functions in higher eukaryotes [1]. The human endothelin system comprises the highly homologous endoth

• ApoE is secreted from astrocytes glia into the

  2021-06-01

  

  ApoE is secreted from astrocytes/glia into the interstitial fluid and is important for metabolizing Aβ because of its propensity for binding Aβ as a cholesterol and phospholipid acceptor in reverse cholesterol transport [8]. Aβ oligomers show a direct toxicity to neurons, and ApoE inhibits oligomer

• br Introduction Type Diabetes mellitus T DM is a

  2021-06-01

  

  Introduction Type 2 Diabetes mellitus (T2DM) is a metabolic disorder that raises blood glucose level for a prolonged time. T2DM is associated with acute complications like ketoacidosis, hyposmolar coma, chronic complications include heart disease, stroke, kidney failure, foot ulcers and damage to

• The ability of minor groove binding agents to

  2021-06-01

  

  The ability of minor groove binding agents to inhibit the activity of DNA helicases is not without precedence. Similar effective inhibition of the unwinding of DNA by the BLM and Werner's DNA helicases by the minor groove binder distamycin A has been observed. Further, and similar to RecBCD, interca

• br Conclusion br Limitations br Conflict of interest

  2021-06-01

  

  Conclusion Limitations Conflict of interest Financial disclosure The research was supported by National Institute of Mental Health and Neuro Sciences (NIMHANS)Intramural Research Grant ID NIMH/PROJ-RSM/545/2014-15. India. Acknowledgments Introduction Increased central and peripher

• The aim of the present study was

  2021-06-01

  

  The aim of the present study was to investigate the participation of CRF1 and CRF2 in the alterations of the dorsal and ventral striatal dopamine release and the vertical and horizontal locomotor activity observed in rats following chronic nicotine treatment and consequent acute withdrawal. In this

• During recent years two primary

  2021-06-01

  

  During recent years, two primary types of models have been applied for calculating various thermodynamic properties of amino Phosphatase Inhibitor Cocktail 2 (100X in ddH2O) mg solutions, i.e. excess Gibbs energy (gE) models used numerously to describe the solubility of amino acid solutions, and eq

• br Material and methods br Discussion First we

  2021-06-01

  

  Material and methods Discussion First, we investigated cannabis use, and results showed that the lifetime prevalence of cannabis use in our sample was 29.63%, with a significant difference between males (73.8% of the abusers) and females (26.2%). Moreover, the mean age and age at onset were si

• More recently it was discovered that BChE

  2021-06-01

  

  More recently, it was discovered that BChE hydrolyzes the neuropeptide gut hormone, ghrelin [25], [26], [27], [28]. Nonetheless, because the enzyme reaction is very slow, those who first reported this finding were initially reluctant to attribute a real physiological role for that phenomenon. Our ow

• In rodent models the loss of

  2021-05-31

  

  In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an E-4031 sale receptor beta agonist restores its protective effect, but is abolished with the introduction of a nitric oxide synthase i

• All these results indicate that cleaving

  2021-05-31

  

  All these results indicate that cleaving embryos possess a regulative mechanism, sensing the number of inner Daprodustat receptor and controlling the proportion of conservative and differentiative divisions of blastomeres. The current observations agree with the results from other laboratories and

• MoAbs targeting the tumourigenic pathways

  2021-05-31

  

  MoAbs targeting the tumourigenic pathways, such as IGF-1R may theoretically have a dual working mechanism. On the one hand they block pathways having an anti-tumour working mechanism, and on the other hand they may also stimulate an immunological response inducing a reaction of the patients own immu

• Ebastine br Materials and methods br

  2021-05-31

  

  Materials and methods Results and discussion Conclusions In the present study, we have shown the important role of miR-204-5p in C2C12 myoblast differentiation. Overexpression of miR-204-5p inhibited myogenic differentiation and decreased the formation of slow-twitch myofibers, whereas miR-

15751 records 618/1051 page Previous Next First page 上5页 616617618619620 下5页 Last page