• Based on these preliminary clinical results with low

  2019-05-15

  

  Based on these preliminary clinical results with low-dose, intermittent zoledronic acid, Hu et al. conducted a randomized phase II clinical study in order to clarify the role of metronomic low-dose zoledronic acid. Sixty breast cancer patients with bone metastases were randomized to receive either 1

• The presence of an inflammatory

  2019-05-14

  

  The presence of an inflammatory infiltrate is associated with poor prognosis in a number of malignancies, including those with a predilection for metastasis to bone. CAFs are capable of promoting, and maintaining an inflammatory environment by recruiting immune cells; in particular monocyte/macropha

• br Materials and methods This study included

  2019-05-14

  

  Materials and methods This study included WCD patients with high risk of SCD but did not meet the eligibility criteria for immediate glp-2 of an implantable cardioverter defibrillator (ICD). Current guidelines endorse indications for WCD therapy [5]. Patients with low left ventricular ejection fr

• Para Rozitchner la di spora proporcionaba la posibilidad de

  2019-05-14

  

  Para Rozitchner, la diáspora proporcionaba la posibilidad de averiguar por qué los sujetos políticos de los años setenta —entre los que se incluía— produjeron una fantasía y una idealidad sobre la materialidad de las fuerzas históricas. Y también, de advertir por qué el terror fue negado y excluido

• But in comes the good news from

  2019-05-13

  

  But in comes the good news from these three NEOVITA studies: there are other effective, feasible interventions that can be implemented everywhere. Rajiv Bahl and colleagues identify that early initiation of breastfeeding and exclusive breastfeeding have independent beneficial effects on neonatal mo

• br Recalls and advisories Managing components under

  2019-05-13

  

  Recalls and advisories Managing components under advisory notices poses several daunting challenges. Fig. 5 illustrates the benefit of HM for the management of recalled components [29,32]. Advisories encompass disintegration of high-voltage circuitry, battery depletion, and lead failure—almost al

• br Adverse events Treatment reported toxicities were

  2019-05-13

  

  Adverse events Treatment reported toxicities were similar to those previously reported [23]. Discussion Several other studies have addressed the same issue using different bisphosphonates. The SABRE study randomised breast cancer patients taking anastrozole with a T-score of between −1 and −2

• Numerous animal studies have demonstrated beyond

  2019-05-13

  

  Numerous animal studies have demonstrated beyond doubt that effective inhibition of osteoclastogenesis or osteoclast function significantly reduces metastatic tumour growth in bone [13–20]. Likewise, clinical trials in patients with non-metastatic or metastatic cancers established that treatment wit

• The cardiac GP are a collection

  2019-05-13

  

  The cardiac GP are a collection of autonomic nervous systems comprising both afferent and efferent as well as sympathetic and parasympathetic fibers [10,11]. Radiofrequency catheter ablation eliminates the most elementary level of vagal innervation by destroying the visceral efferent limb of the par

• br Discussion SIS is a morphological characteristic

  2019-05-13

  

  Discussion SIS is a morphological characteristic of the basal interventricular septum that protrudes into the LV cavity. This cardiac malformation has generally been considered a natural part of aging without pathophysiological or clinical significance [5,6]. However, several studies demonstrated

• Current treatment options for paroxysmal supraventricular ta

  2019-05-13

  

  Current treatment options for paroxysmal supraventricular tachycardias include AV norepinephrine bitartrate blocking agents (verapamil, diltiazem, propranolol, and metoprolol), class IC anti-arrhythmic agents (propafenone and flecainide), and catheter ablation. The identification of frequent coexis

• The results of our initial cross sectional analyses assessin

  2019-05-13

  

  The results of our initial cross-sectional analyses assessing the clinical characteristics of the patients participating in ASSAF-K are shown in Table 1. As compared with the “Fushimi AF Registry,” considered a representative Japanese AF registry with an initial registration of 3183 patients [28], t

• Hay que remontar a la Guerra Civil espa ola

  2019-05-13

  

  Hay que remontar tankyrase la Guerra Civil española que movilizó a los poetas hispanoamericanos de una manera mucho más urgente que la Segunda Guerra Mundial, para hallar el origen de los lazos de Octavio Paz con Chile. En 1937 Octavio Paz recibió una invitación para participar en el Congreso Intern

• El otro paradigma cuyo alcance y magnitud

  2019-05-13

  

  El otro paradigma cuyo alcance y magnitud exige atención particular es la deconstrucción y todo el giro lingüístico que la precede, un enfoque en muchos sentidos inverso nitric oxide inhibitor la colonialidad, aunque no en todos. Sus cauces precursores en América Latina podrían partir de figuras com

• Podemos seguir con ejemplos espigados el plan de instrucci

  2019-05-13

  

  Podemos seguir con ejemplos espigados: el plan de instrucción pública del peruano Hipólito Unanue, tras la obligada crítica al antiguo régimen, preveía estudios de “humanidades y filosofía en lengua vulgar entrando después en el estudio del latín los que lo hubieran menester”. En Venezuela se quiso

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