• We previously discovered that ATM in addition

  2018-11-08

  

  We previously discovered that ATM, in addition to serving many roles in cell-cycle regulation and DNA damage response, also functions as a key epigenetic regulator in neurons, likely underlying the ataxic symptoms as well as neurodegeneration. ATM indirectly regulates nuclear-cytoplasmic shuttling o

• In the present study we show that

  2018-11-08

  

  In the present study, we show that rhLNs are more effective in supporting xeno-free and defined differentiation compared with exogenous matrix such as gelatin, used in ongoing clinical studies (Schwartz et al., 2012). Moreover, we demonstrate that suspension transplantations of rhLN-521-hESC-RPE int

• Many non integrating reprogramming strategies have been

  2018-11-08

  

  Many non-integrating reprogramming strategies have been investigated over the past 8 years, such as minicircle plasmids, synthetic mRNA/miRNA, proteins, and small molecules. However, all these approaches are labor intensive, time consuming, and often inefficient. Recently, much attention has been fo

• Fetal hepatocyte progenitors express EZH the

  2018-11-07

  

  Fetal hepatocyte progenitors express EZH2, the histone lysine methyltransferase responsible for H3K27 trimethylation, and EZH2 is required to allow hepatocyte progenitor expansion in vivo (Koike et al., 2014). Conversely, knockdown of EZH2 in embryonic murine hepatic progenitors was reported to prom

• It seems reasonable to conclude that the

  2018-11-07

  

  It seems reasonable to conclude that the Dutch, who exhibit an independent self-construal and are strongly individualistic, use the occasion of helping colleagues as a way to express their pride publicly and standout. This interpretation is consistent with the emotional syndrome description of North

• br Theoretical model br Empirical model In order to

  2018-11-07

  

  Theoretical model Empirical model In order to test whether the effects of labor productivity and exchange rate indeed differ, as predicted by the theoretical model, we estimate the elasticities of each variable in Eq. (13). To implement this test empirically, we make modifications in the estim

• br Methods Twenty Wistar adult male rats g

  2018-11-07

  

  Methods Twenty Wistar adult male rats (280–300g) were used in this study. The animals were maintained with food and water ad libitum, and kept under controlled conditions (temperature 22±2°C; 12:12-h light-dark cycle). All of the experimental procedures were conducted in accordance with the Guide

• In addition to the burden on

  2018-11-07

  

  In addition to the burden on the population, it is hypothesized that the considerable health and care burden of AD will impose a large economic burden throughout affected economies. Previous economic studies estimate the 2009 worldwide cost of dementia to be US$421 billion and attribute 10% of the g

• Our work shows some inherent limitations

  2018-11-07

  

  Our work shows some inherent limitations. The fact that the patients were heterogeneous in fasting time, as well as differences in gender, etiology, pharmacological treatment or age, to name a few, could hinder some potential biomarkers. Moreover, plasma metabolites levels could be influenced by man

• melanotropin The mechanism of enhanced anti tumor activity o

  2018-11-07

  

  The mechanism of enhanced anti-tumor activity of the FASN and taxane drug combination in our studies includes sensitization of tumor melanotropin to FASN inhibition-mediated gene expression changes and inhibition of beta-catenin signaling but not Akt signaling. It remains possible that sensitizatio

• To summarize our work highlights the facts that ECs maintain

  2018-11-07

  

  To summarize, our work highlights the facts that ECs maintain HIV-specific memory B cell responses associated to effective antiviral humoral activities and that Env-specific memory B cell responses are positively associated with the neutralization breadth in HLA-B*57+ ECs. We propose that promoting

• Our assessment also takes into account the identification of

  2018-11-07

  

  Our assessment also takes into account the identification of alternative proteins (AltProts) (Vanderperre et al., 2013). AltProts are translated from alternative open reading frames (AltORFs). AltORFs can have different localizations: they can overlap annotated protein-coding sequences in a differe

• br The Interferon Signature IFNs are a

  2018-11-07

  

  The Interferon Signature IFNs are a group of pro-inflammatory cytokines. To date, three types of IFNs have been identified: type I (which includes IFNα, IFNβ, IFNε, IFNκ and IFNώ), type II (IFNγ), and the recently discovered type III (IFNλ) (Donnelly and Kotenko, 2010; Sheppard et al., 2003). Th

• beta adrenergic blockers br Materials and methods br Acknowl

  2018-11-07

  

  Materials and methods Acknowledgments This work was supported by a grant from the Novo Nordisk Foundation, the Lundbeck Foundation, and the Augustinus Foundation. N.O. is supported by the Lundbeck Foundation. I.K. is supported by grants from the Danish Natural Science Research Council and the

• NMR data were acquired on Bruker AVANCE III HD MHz

  2018-11-07

  

  NMR data were acquired on Bruker AVANCE III HD 600MHz, AVANCE III HD 700MHz, and AVANCE III HD 800MHz spectrometers, each equipped with a cryogenic probe. NMR experiments used are summarized in Table 1. Experimental design, materials and methods Acknowledgments This work was supported by the

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