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br Lymphoplasmacytic lymphoma Waldenstrom macroglobulinemia
2020-04-15
Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia Lymphoplasmacytic lymphoma (LPL) and its subgroup Waldenstrom macroglobulinemia (WM) are rare and indolent lymphomas that arise from fully differentiated B cells. The only family of GPCRs that has been well studied in LPL/WM is the chemokin
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br Oxysterols as Key Players in Metabolic Syndrome Obesity a
2020-04-15
Oxysterols as Key Players in Metabolic Syndrome? Obesity and sedentary lifestyle are on the rise and pose serious threats to people\'s health and wellbeing. Obesity is often associated with other pathologies and is one of the criteria included in the definition of metabolic syndrome (MetS) (see G
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For this reason we hypothesized that the DHFR gene could
2020-04-15
For this reason we hypothesized that the DHFR gene could be a potential candidate in clefting. Our data, obtained using a family-based association approach, evidenced an association with borderline significance for the SNP rs1677693. The variant allele A at this marker seems to reduce the risk of C
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The data in our manuscript confirm previous
2020-04-15
The data in our manuscript confirm previous data on the origin of CMV-specific T Irinotecan following TCD alloSCT in CMV seropositive patients transplanted with a CMV seronegative donor (R+D−) and demonstrate that also recipient CMV-specific memory T-cells are able to survive alemtuzumab based TCD
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Acknowledgments br Introduction Steroidogenesis the process
2020-04-15
Acknowledgments Introduction Steroidogenesis, the process of testosterone synthesis, occurs in the adrenal cortex, testis and ovary, and it is controlled by luteinizing hormone (LH), which is synthesized and secreted from the pituitary (Hanukoglu, 1992, Payne and Youngblood, 1995). In the testis
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To further confirm the roles of the CYP
2020-04-15
To further confirm the roles of the CYP450 enzymes involved in the metabolism of Dip in rat liver microsomes, we utilized not only chemical inhibitors but also a correlation analysis and a panel of recombinant rat CYP450 enzymes to evaluate the contribution of CYP450 enzymes. The results of the corr
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Bcl functions as a transcription repressor
2020-04-15
Bcl6 functions as a transcription repressor via its N-terminal BTB domain and middle “second repression,” or “RD2” domain (Chang et al., 1996, Seyfert et al., 1996). A loss of function of the BCL6 BTB domain markedly impairs survival and proliferation of mature GC Ac-YVAD-CHO australia in a B cell
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The molecular mechanisms regulating the differentiation
2020-04-15
The molecular mechanisms regulating the differentiation of Th1 versus Tfh BYL-719 from IL-12-stimulated CD4+ T cells remain largely uncharacterized in humans. This topic has been extensively studied in mice (Weinmann, 2014), because IL-12 stimulation promotes mouse naive CD4+ T cells to express both
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Therefore the SPH algorithm in AUTODYN D was used to
2020-04-14
Therefore, the SPH algorithm in AUTODYN-3D™ was used to simulate the experiment in Ref. [5] to verify the credibility of the numerical simulation method by results that could be measured accurately. Then the verified numerical simulation method was used to simulate BAD generated by RHA subjected to
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br Substrate Specificity Discrimination and Binding Energy I
2020-04-14
Substrate Specificity, Discrimination, and Binding Energy In Bleomycin A5 hydrochloride mg to catalytic efficiency, which can be gauged in reference to an absolute scale of ‘catalytic perfection’ 10, 11, specificity is a relative concept because it requires comparison between given alternative s
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Among the high value compounds derived from agricultural
2020-04-14
Among the high value compounds derived from agricultural residues there are enzymes with industrial application. The extraction processes have been focused on the development of new strategies that guarantee high recovery rates with maximum activity (Nadar et al., 2017). The residues of these two f
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hsp90 inhibitor Because sex steroids and growth hormone play
2020-04-14
Because sex steroids and growth hormone play an important role in the development and maintenance of hepatic CYP450 enzyme expression and ER expression, it is possible that exposure to endocrine active agents during gestation and perinatally could alter expression of these proteins. Therefore, these
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DGK is not the only DGK isoform that
2020-04-14
DGKε is not the only DGK isoform that has been associated with p53. It has been shown that DGKζ binds to p53 and modulates its activity in both the cytoplasm and the nucleus [39]. In the cytosol DGKζ promotes the degradation of p53 through the ubiquitin-proteosome system [39], also a likely mechanis
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br Experimental section br Notes br PDB ID
2020-04-14
Experimental section Notes PDB ID codes The atomic coordinates and structure factors of hDHODH in complex with compounds 4 (PDB id: 5MVC), 5 (PDB id: 5MVD) and 6 (PDB id: 5MUT) have been deposited in the RCSB Protein Data Bank. Acknowledgements This research was financially supported by
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Z-LEHD-FMK br Fragment based drug discovery FBDD
2020-04-14
Fragment-based drug discovery (FBDD) is a powerful method to discover drug leads and has been widely adopted in both academia and industry. FBDD can be used to explore chemical Z-LEHD-FMK space with libraries which are smaller in size, producing drug leads with high ligand-binding efficiency. It a
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