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Kinetic isotope effects KIEs inform on bond vibrational chan
2019-10-01
Kinetic isotope effects (KIEs) inform on bond vibrational changes between the ground state (GS) and TS of a chemical reaction and remain one of the most powerful experimental techniques for interrogating TS structure. KIEs on enzyme reactions measured by the internal 99026 of labeled substrates rep
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br Materials and methods br Results br Discussion
2019-10-01
Materials and methods Results Discussion In addition, the responses of CYP450s induced by metalaxyl are species-specific in the four cells. For example, metalaxyl lead to induction of CYP1A1, CYP1A2, and CYP2B1 in HepG2 cells, CYP1A2 and CYP2B1 in H4IIE cells, CYP1A1 and CYP2B1 in LMH cells
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Carbetocin pathway Neuronal cells have highly developed ER w
2019-10-01
Neuronal Carbetocin pathway have highly developed ER, which makes them susceptible to loss of ER function following exposure to various agents, which leads to apoptosis (Lindholm et al., 2006, Katayama et al., 2004). Multiple pathways may be involved in ER stress-initiated apoptosis. Among them, th
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br Multi subunit RINGs There are RING type E s
2019-10-01
Multi-subunit RINGs There are RING-type E3s that exist as multi-subunit assemblies (see Fig. 3B). A striking example is the Cullin RING Ligase (CRL) superfamily [35], which exhibits enormous plasticity in substrate specificity. Each CRL subfamily is characterized by a cullin protein (Cul-1, 2, 3,
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Importantly in genetic studies Saccharomyces cerevisiae
2019-10-01
Importantly, in genetic studies, Saccharomyces cerevisiae Pif1, a member of the SF1 family of helicases, has been implicated in BIR in conjunction with Pol δ (Chung et al., 2010, Saini et al., 2013, Wilson et al., 2013). Using highly purified S. cerevisiae proteins, a system that permits dissection
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One step in pyrimidine biosynthesis is conversion of
2019-10-01
One step in pyrimidine biosynthesis is conversion of l-dihydroorotate (DHO) to orotate (ORO), under action of the enzyme dihydroorotate dehydrogenase (DHODH, EC 1.3.99.11), which contains a flavine (FMN) as redox cofactor [1]. In this transformation, electrons resulting from DHO oxidation are transf
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In conclusion our work provides the preclinical
2019-09-30
In conclusion, our work provides the preclinical evidence showing the potent in vivo efficacy of AT7519 on chemoresistant cancer Temsirolimus and its underlying mechanisms of action. Our work supports the biological rationale behind the clinical trials initiated with AT7519, particularly for the tr
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In conclusion adipose PGD suppressed the lipolysis by
2019-09-30
In conclusion, adipose PGD2 suppressed the lipolysis by decreasing the intracellular cAMP level through DP2R. Therefore, PGD2 enhanced adipocyte differentiation (lipid accumulation) through both repression of the lipolysis via DP2R and activation of the lipogenesis via PPARγ. Thus, L-PGDS and DP2R a
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We did not find any
2019-09-30
We did not find any significant associations between APOE genotype and BDI-II, BAI, or PAI clinical scale scores. Our results indicate that APOE is not likely to play a major role in psychiatric comorbidities in epilepsy. This is in line with studies in the general population, which have not found a
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Materials and methods br Results br Discussion Microbial pro
2019-09-30
Materials and methods Results Discussion Microbial production of trans-4Hyp, an added-value amino Sulfasalazine for pharmaceuticals, offers significant advantages over conventional chemical extraction in economic and environmental aspects. However the low titer and productivity with the exis
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pdgf receptor Previous research has suggested that the acety
2019-09-30
Previous research has suggested that the acetylcholine-gated chloride channels (ACCs) in Caenorhabditis elegans (Putrenko et al., 2005) exhibit the characteristics of promising drug targets. The genes that encode the various subunits of this family are present across the nematode phylum and appear t
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Previous studies in the Swiss Webster mouse Rosengren et
2019-09-30
Previous studies in the Swiss Webster mouse (Rosengren et al., 1995) and the Sprague–Dawley rat (El Sisi et al., 1993) have shown that retinol pretreatment potentiates the hepatotoxicity of paracetamol. The current study is designed to investigate further this interaction in mice. To accomplish this
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Ubiquitination is a reversible posttranslational modificatio
2019-09-30
Ubiquitination is a reversible posttranslational modification. The removal of Ub is carried out by enzymes known as deubiquitinases (DUBs). The antagonistic role played by these enzymes in the Ub pathway regulates the function of the ubiquitinated proteins, while maintaining the free Ub pool in euka
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We found that the postnatal absence of norepinephrine yields
2019-09-30
We found that the postnatal absence of norepinephrine yields differing effects depending on noradrenergic receptor type and cytokine receptor region. The density of α1-AR, indicated by [3H]prazosin binding was similar between Dbh+/− and Dbh−/− mice except for a significant increase in hippocampus i
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br Rationale and Conventional Use of Alkylating Agents and
2019-09-30
Rationale and Conventional Use of Alkylating Agents and Platinum Derivatives in Clinical Practice After the attack on Bari Harbor in 1943 revealed the effects of mustard gas on bone marrow depletion and the first therapeutic outcomes in lymphoma, alkylating agents gradually became a gold standard
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