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br Inhibition of DHODH The final products
2019-10-12
Inhibition of DHODH The final products 7a–n were assessed for their DHODH inhibitory activity on rat liver mitochondrial/microsomal membranes. A procedure adapted from the literature was employed (see Experimental), in which oxidation of DHO to ORO is monitored by following the concomitant reduct
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Clofarabine kinase br Materials and methods br
2019-10-11
Materials and methods Results Discussion One novel finding in our study is that CK2 inhibition preserved axon function and structure in WM against ischemia. Consistent with these findings, oligodendrocytes, astrocytes, myelin, and Clofarabine kinase were found to express CK2α. The robust e
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In the present study we investigated the effect
2019-10-11
In the present study we investigated the effect of morphine withdrawal on G-protein coupling to opioid and ET receptors in neonatal rats. Morphine-induced G-protein activation was significantly higher in neonatal rats undergoing morphine withdrawal; suggesting enhanced coupling of the receptors to G
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For this study we have used the intermediate
2019-10-11
For this study we have used the intermediate affinity mutant antigen HEL2× for immunization. However, we have observed a similar defect in the plasmablast differentiation of EBI2-deficient SWHEL Pyrintegrin pathway over a 10,000-fold affinity range by using WT HEL or the low-affinity mutant HEL3× (
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Mulan protein level is regulated with
2019-10-11
Mulan protein level is regulated with conditions that stimulate mitophagy such as treatment of Mouse HGF / Hepatocyte Growth Factor Protein (His Tag) with CCCP [12]. We found that exogenously expressed GFP-GABARAP and RFP-Mulan could co-precipitate and co-localize in mammalian cells and the degree
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By stratifying EOC cell lines according to their
2019-10-11
By stratifying EOC cell lines according to their EMT stages, we observed a significant higher expression of DDR1 in the epithelial-like cell lines compared to low or undetectable DDR1 in mesenchymal-like cell lines. Similar trend was observed in the tumour samples, with the lowest expression of DDR1
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We thank Dr Hongqiang Qin at Dalian
2019-10-11
We thank Dr. Hongqiang Qin at Dalian Institute of Chemical Physics, Chinese Academy of Sciences for technical assistance in mass-spectrometric analysis. We thank Prof. Quentin Liu at Dalian Medical University and Prof. Qiang Shen at M.D. Anderson Cancer Center for helpful discussion and comments. Dr
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CK enzymes belong to a
2019-10-11
CK1 enzymes belong to a conserved family of serine/threonine protein kinases that plays an important and diverse role in vesicular trafficking, DNA repair, TNF-alpha, recombinant murine protein progression and cytokinesis in organisms from yeast to humans [15]. In multicellular organisms CK1 enzyme
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br Results br Discussion In this paper we present
2019-10-10
Results Discussion In this paper we present insights into the observed specificities of inhibitors targeting the ubiquitin-activating and related E1 FPS-ZM1 via crystal structures of the specific NEDD8-E1 inhibitor MLN4924, the dual NEDD8/Ub E1 inhibitor ABPA3, and the selective Ub-E1 inhibit
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Real time PCR as described previously with minor modificatio
2019-10-10
Real-time PCR, as described previously with minor modifications, was used to detect DNA . The PCR mixture (Qiagen) was as follows: 5mM MgCl2, 2.5μl of 10x PCR Buffer, 0.125μl of HotStarTaq DNA Polymerase, 0.25mM of each dNTP, 0.4μM of each primer and 0.1μM of FAMlabelled probe (‘5-aacaattggagggcaag
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It has been shown that DAPK
2019-10-10
It has been shown that DAPK induces cell death through an increase in DAPK catalytic activity and subsequent phosphorylation of target proteins (Shang et al., 2005, Yamamoto et al., 2002), but its multidomain structure enables also a close physical interaction with other proteins (Bialik and Kimchi,
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We propose two hypotheses to interpret our findings The
2019-10-10
We propose two hypotheses to interpret our findings. The first, ELR (+) CXC chemokines stimulate both CXCR-1 and CXCR-2 chemokine receptor while activating neutrophils; however CXCR-1 chemokine receptor seems to play more active role in the process of neutrophil migration as shown in previous studie
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Oleandrin The P H activity and the
2019-10-10
The P4H activity and the large number of 4-Hyp residues that are formed, amounting to half of all the Pro residues or 10% of all residues, have been identified as having a clear role in the structure and chemistry of the triple helix [3]. The role of the rare 3-Hyp residues is less clear and is stil
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During ischemia the impact of CK on mitochondria varies
2019-10-10
During ischemia, the impact of CK2 on mitochondria varies in different organs/tissues. For example, CK2α upregulation during ischemia leads to disrupted mitochondrial homeostasis and mediates cardiomyocyte ischemic injury [31]. Specifically, ischemia/reperfusion (I/R) progressively increases CK2α to
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br Acknowledgements This study is
2019-10-10
Acknowledgements This study is sponsored by the Natural Science Foundation of China (grant no. 51178161), 111 Project (grant no. B13024) and the Fundamental Research Funds for the Central Universities (grant no. 2017B00914) Introduction Highway and pavement engineers are facing concrete pavem
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