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In vitro study indicated the cell death of hippocampal
2020-10-26
In vitro study indicated the cell death of hippocampal neurons was mediated by DAPK1 following ceramide-3 treatment (Pelled et al., 2002). the same study showed that DAPK1-deficient mice treated by acyl ceramide exhibit a less sensitivity to apoptosis, this proposed that DAPK1 plays a central role i
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br Funding This work was supported by a research
2020-10-26
Funding This work was supported by a research grant of the Deutsche Forschungsgemeinschaft (SCHN477-9-2 to R.S.S), the Manfred-Stolte-Stiftung (to R.S.S.) and by a research grant from the German Cancer Aid (Deutsche Krebshilfe, No. 106696/TP 5 to T.F.). Introduction Death-associated protein k
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Here we also took attempt to evaluate
2020-10-26
Here we also took attempt to evaluate the CYP mediated inhibition potential of S. chirata and its biomarker ursolic GYKI 52466 dihydrochloride mg on pooled RLM by CYP-CO complex assay. We observed that S. chirata extract and ursolic acid showed less enzyme inhibition than known inhibitor (ketoconaz
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Testosterone is inactivated through hydroxylation and conjug
2020-10-26
Testosterone is inactivated through hydroxylation and conjugation pathways [3], [4]. 6β-Hydroxylation is the main pathway among testosterone hydroxylation processes in the liver microsome. Testosterone 6β-hydroxylation is mainly catalyzed by cytochrome P450 3A (CYP3A) [5], [6], which is expressed in
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gap-27 Indeed some cancers may even be defined by dysregulat
2020-10-26
Indeed, some cancers may even be defined by dysregulated cyclin and thus CDK activity: mantle cell lymphoma, an uncommon lymphoma of mature B cells, is defined by the presence of overexpressed cyclin D1, usually as a result of a translocation between chromosomes 11 and 14 with the net result that cy
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br Results br Discussion br Conclusions The present study de
2020-10-26
Results Discussion Conclusions The present study demonstrates that CRF1 receptor-deficiency prolongs whereas CRF2 receptor-deficiency shortens the duration of recognition memory deficits induced by morphine discontinuation, unraveling opposite roles for the two known CRF receptor subtypes i
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Constitutive activity of Ras Raf MEK ERK pathway plays
2020-10-23
Constitutive activity of Ras/Raf/MEK/ERK pathway plays a critical role on melanoma growth, thus inhibition of activity of Ras, Raf and MEK can reduce ERK activity, leading to a decrease in melanoma cell proliferation, survival and invasion (Burotto et al., 2014; Paluncic et al., 2016). Our results a
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In the previous study glutamyl endopeptidase of B intermediu
2020-10-23
In the previous study glutamyl endopeptidase of B. intermedius has been reported to be distributed in the cathepsin inhibitors of B. intermedius as follows: 90% of synthesized enzyme has been detected in the culture liquid, 9.3% of glutamyl endopeptidase—in the fraction of membrane proteins [20]. T
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br Conflict of interests br Introduction Ubiquitylation is a
2020-10-23
Conflict of interests Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell. Dysregulation of the ubiquitylation pathway is associated with several diseases, including cancer, neurodegenerative disorders, and immunological dy
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In children only the genotype was
2020-10-23
In children, only the 6/7 genotype was associated with spina bifida, increasing the risk about 4 times relative to the DHFR 3/3 and 6/6 genotypes. However, the 95%CIs are broad and only few spina bifida patients have the DHFR 6/7 genotype. The effect of the 6/7 genotype on spina bifida risk is there
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br Role of cysLT signaling
2020-10-23
Role of cysLT signaling on various neurological complications which are associated with Alzheimer’s disease Alzheimer’s disease, first described in 1906 by Alois Alzheimer, is a neurodegenerative disease and a very common cause of dementia progressively leading to death. Even though years of rese
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br Materials and methods br
2020-10-23
Materials and methods Results As shown in Table 1, blood urea nitrogen and serum creatinine levels were significantly elevated at both 1st and 7th days of pyelonephritis, when compared with those of the control group (PPotassium Canrenoate formation or intratubular neutrophils, while tubules
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Social interaction is known to be
2020-10-23
Social interaction is known to be the main source of stress in human beings (Dickerson and Kemeny, 2004, Tamashiro et al., 2005). An animal model of social stress should closely mimic real-life situations in human life (Neisewander et al., 2012); in this context, social defeat in an agonistic encoun
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Social memory is encoded within certain
2020-10-23
Social memory is encoded within certain sites, but meaning depends upon an interpretant (such as a tourist) being able to decode the signs. Memorials, such as cemeteries, require some kind of activity by its visitors for their meanings to be activated (Hutchinson, 2009, Winter, 2010). Following Eden
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Present study observed failure of
2020-10-23
Present study observed failure of PPE usage by the majority of workers, which may be notable problem and may create a significant health effects due to pesticide exposure. Non-usage of PPE and its ill effects have been reported among farmers in Brazil [24,25] and Nepal [26]. It was reported that use
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