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In conclusion we have found that Egr
2020-07-03
In conclusion, we have found that Egr1 can play an inhibitory role on DBH promoter-driven transcription. This inhibition requires a newly identified Egr1 response proton pump inhibitor at the −227/−224 region of DBH promoter. This inhibition appears to result from Egr1 directly bound to the DBH pro
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Renal injury by cisplatin has been associated with oxidative
2020-07-03
Renal injury by cisplatin has been associated with oxidative stress, inflammation, and apoptosis (Francescato et al., 2007, Iseri et al., 2007, Kiymaz et al., 2008, Ueki et al., 2012). Specifically, apoptosis is an important mode of cell death in cisplatin nephrotoxicity, and many studies including
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A major open question in the field of lipid
2020-07-02
A major open question in the field of lipid mediators is the molecular nature of the PLA2 enzyme involved in the release of DHA and related omega-3 fatty acids from phospholipids as a first committed step for the generation of SPMs. Although by analogy with AA it is often assumed that cPLA2α may ser
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br Acknowledgments br Multicellular organisms respond rapidl
2020-07-02
Acknowledgments Multicellular organisms respond rapidly, and adapt to cellular stress to maximize cell survival. The cellular stress response, also called (ISR), is universally conserved and independent of the stressor. ISR induces rapid, transient reprogramming of cellular protein translation
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br Discussion Previous studies have reported conflicting ass
2020-07-02
Discussion Previous studies have reported conflicting association results between the functional variant DBH −1021C>T and PD [8], [9]. Our findings would suggest that DBH −1021C>T does not dramatically decrease the risk of disease although it may marginally affect symptomatic AAO. However, whethe
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In order to assess quantitatively the contribution of the
2020-07-02
In order to assess quantitatively the contribution of the ung, dug and dut AZD-4547 to uracil-DNA accumulation in E. coli, we have developed a novel method for measuring uracil residues in DNA that is based on the approach of Kow and co-workers [33] for measuring AP-sites in DNA. The method, which
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br Materials and methods br Results br Discussion Our
2020-07-02
Materials and methods Results Discussion Our study assessed the cytokine and chemokine changes associated with first onset PP as compared to HP and HNP groups. In the monocytes/ macrophages/ dendritic ro5 panel, IL-6 levels were found to be significantly elevated in both HP and PP groups wh
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THZ531 br Materials and methods br
2020-07-02
Materials and methods Acknowledgements We thank Drs. Nathan Sherer (University of Wisconsin-Madison) and Bryan Cullen (Duke University) for generous reagent gifts. The following reagent was obtained through the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH: HIV-2ROD phage from Dr. Ron
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br Methods and materials br
2020-07-02
Methods and materials Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic GSK503 to prostaglandin, prostacyclins and thromboxanes., , , Two distinct isoforms of COX were initially discovered: COX-1 is a constitutive, housekeeping enzyme that is expressed in many
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br Acknowledgments br Introduction Understanding the charact
2020-07-02
Acknowledgments Introduction Understanding the characteristics of the Amazonian Dark soils “Terras Pretas de Índio” (TPIs) is of ecological importance, because the TPI soils represent a residue-based model for tropical sustainable agriculture (Sombroek et al., 2003, Neves et al., 2003, Cohen-O
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ochratoxin a Asteroids can provide an abundant supply of oth
2020-07-01
Asteroids can provide an abundant supply of other resources, such as carbon, nitrogen, or calcium compounds, but will only be useful once the space economy is sufficiently developed to provide economically interesting uses for them. Others, such as titanium or aluminium, also exist in asteroids, but
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The COMT gene is involved in numerous psychological
2020-07-01
The COMT gene is involved in numerous psychological and physiologic processes, including modulation of pain. Polymorphisms in this gene have also been associated with many painful conditions, including pain sensitivity in children. Bivariate analysis demonstrated that individuals with heterozygous C
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Tacrine amino tetrahydroacridine I Fig was the first AChEI
2020-07-01
Tacrine (9-amino-1,2,3,4-tetrahydroacridine) (I, Fig. 1) was the first AChEI to be approved by the Food and Drug Administration (FDA) for the treatment of AD [25], [26], [27], [28]. However, despite its good AChE inhibitory activity, tacrine was far from ideal due to its low bioavailability and shor
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In the literature we can find two different modes of
2020-07-01
In the literature, we can find two different modes of action for estrogens: Firstly there is the commonly accepted genomic pathway. Estrogens pass the cell membrane due to their lipophilic character via diffusion and bind to estrogen receptors (ERs) in the cytoplasm. After binding a dimerization of
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There is a considerable molecular genetic
2020-07-01
There is a considerable molecular genetic heterogeneity within ES/PNET. As mentioned above, either or can rearrange with in these gene fusions. Furthermore, for either gene fusion, additional heterogeneity stems from the location of the genomic breakpoints of the translocation, resulting in diffe
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