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As demonstrated by Soyombo and colleagues neointima formatio
2020-07-31
As demonstrated by Soyombo and colleagues [28], neointima formation is a phenomenon that can be successfully replicated in ex vivo human saphenous vein organ cultures, which is therefore a valuable technique for the testing of novel therapeutic interventions. Utilising this model, we demonstrated th
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br Associations between striatal D Rs and
2020-07-30
Associations between striatal D2Rs and disease Various disorders that are known to involve dysfunction of the dopamine system also exhibit D2R alterations in striatum. In some cases, D2R involvement has been inferred from the ability of D2R-based drugs to successfully treat disease symptoms or to
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It was found that inhibiting TdT in some cancer cells
2020-07-30
It was found that inhibiting TdT in some cancer cells can kill them, such as in acute lymphoblastic leukemia cells [86]. Chemical compounds were designed and synthesized using TdT as a drug target [87, 88] and the structure of some of these compounds was solved in their bound form []. The length of
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br Data availability br Acknowledgments The
2020-07-30
Data availability Acknowledgments The work was supported in Department of Biochemistry by grants from British Heart Foundation (SP/15/7/31561, FS/15/20/31335 and RG/15/4/31268). At the Department of Materials Science, Cambridge, funding was from the People Programme of the EU 7th Framework Pro
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Rubber biosynthesis of rubber trees is a typically
2020-07-30
Rubber biosynthesis of rubber trees is a typically plant secondary metabolism of isoprenoid pathway [16]. Some studies reported that jasmonic procollagen c proteinase (JA) was an effector that could regulate the secondary metabolism of plants [17], [18], [19]. To elucidate the molecular mechanisms
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br Materials and methods br Results br Discussion Growing kn
2020-07-30
Materials and methods Results Discussion Growing knowledge of cancer genomes, epigenomes and biology led to the comprehension that, in most cases, a combination of alterations is required for tumorigenesis. While some tumor promoting alterations are frequently found, and the corresponding g
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We previously found that the introduction of a methyl
2020-07-30
We previously found that the introduction of a methyl group on the C2 Cy3 maleimide (non-sulfonated) of TBBi led to the 4,5,6,7-tetrabromo-2-methyl-1H-benzimidazole (2MeTBBi) with a promising inhibitory activity of CK2 and PIM1 and with increased cytotoxicity against CCRF-CEM and MCF-7 cells [19].
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As a functional ETC is required
2020-07-29
As a functional ETC is required for DHODH catalysis (Loffler, Jockel, Schuster, & Becker, 1997; Rawls, Knecht, Diekert, Lill, & Loffler, 2000; Zameitat, Freymark, Dietz, Loffler, & Bolker, 2007), DHODH depends on the mitochondrial ETC to generate adequate concentrations of ubiquinone (Fig. 2). Cells
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In this study the substantial evidence in favour of
2020-07-29
In this study, the substantial evidence in favour of the association between the risk of developing vitiligo and CDH1 and DDR1 Malonic acid polymorphisms reported in previous studies was confirmed. However, the small sample size was considered to be a limitation of this case-control study, and it sh
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In general these results suggested
2020-07-29
In general, these results suggested that EP300 and DDR1 synergistically acted as therapeutic regulators of TGF-β1 signaling in pulmonary fibrosis. Both EP300 and DDR1 SP 600125 were significantly up-regulated in IPF patients, and EP300 exerted potential fibrotic effects by activating DDR1 expressio
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Finally the carbamate monomer and dimer prodrugs and
2020-07-29
Finally, the carbamate monomer and dimer prodrugs and were incubated with 1U of CPG2 and both compounds were shown to be good substrates (). The monomer prodrug was completely converted into the cytotoxic parent PBD within 50min with no apparent chemical degradation observed in the assay buffer
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One of the most fundamental distinctions between Ub signals
2020-07-28
One of the most fundamental distinctions between Ub signals is substrate monoubiquitination versus polyubiquitination. With the exception of the E2, UBE2W, which represents a special case because it Anastrozole only ubiquitinates the flexible N-termini of substrates [5], [6], [20], most examples of
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WZ811 australia C PHNO has been described as a
2020-07-28
[11C]-(+)-PHNO has been described as a full agonist at both D2 and D3 receptors [54,55]. [11C]-(+)-PHNO was initially developed as a PET radiotracer for imaging the high affinity state of the D2 receptor (i.e., highD2) as a means of measuring synaptic dopamine changes in response to pharmacologic ch
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Converging evidence indicated a possible connection between
2020-07-28
Converging evidence indicated a possible connection between hyperthermic and neurotoxic responses of AMPHs [[52], [53], [54]]. Earlier reports suggested that MA-induced hyperthermia may be important for striatal dopamine depletion [52], formation of dopamine quinones [55], and thereby production of
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We also performed a correlation analysis
2020-07-28
We also performed a correlation analysis independent of annotated gene sets to identify potentially novel genes that are co-expressed with DHODH. Using the top 100 DHODH co-expressed genes in COAD, LGG, STAD, and PAAD diseases, we identified four common genes across all four diseases (Fig. 9). These
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