Archives
- 2018-07
- 2018-10
- 2018-11
- 2019-04
- 2019-05
- 2019-06
- 2019-07
- 2019-08
- 2019-09
- 2019-10
- 2019-11
- 2019-12
- 2020-01
- 2020-02
- 2020-03
- 2020-04
- 2020-05
- 2020-06
- 2020-07
- 2020-08
- 2020-09
- 2020-10
- 2020-11
- 2020-12
- 2021-01
- 2021-02
- 2021-03
- 2021-04
- 2021-05
- 2021-06
- 2021-07
- 2021-08
- 2021-09
- 2021-10
- 2021-11
- 2021-12
- 2022-01
- 2022-02
- 2022-03
- 2022-04
- 2022-05
- 2022-06
- 2022-07
- 2022-08
- 2022-09
- 2022-10
- 2022-11
- 2022-12
- 2023-01
- 2023-02
- 2023-03
- 2023-04
- 2023-05
- 2023-06
- 2023-07
- 2023-08
- 2023-09
- 2023-10
- 2023-11
- 2023-12
- 2024-01
- 2024-02
- 2024-03
- 2024-04
- 2024-05
- 2024-06
- 2024-07
- 2024-08
- 2024-09
- 2024-10
-
Unlike previous studies examining COMT genotyping in
2020-08-06
Unlike previous studies examining COMT genotyping in healthy controls seeking to explain impulsive behaviors, this study sought to examine COMT genotypes in a large sample of individuals with varying levels of gambling behavior to determine whether COMT AZD-9291 mesylate was associated with differe
-
BEC australia Despite the evidence accumulated on the involv
2020-08-06
Despite the evidence accumulated on the involvement of ETs and their receptors in many pain states, their potential contribution to nociception following SCI has not yet been investigated. Hence, the present study was designed to assess the roles exerted by ETAR and ETBR in neuropathic pain after SC
-
In this study we investigated whether the
2020-08-05
In this study, we investigated whether the Ednra signaling is involved in Hoxa9/Meis1-mediated leukemogenesis. We found an upregulation of Ednra in leukemic murine bone marrow (BM) Novobiocin Sodium australia overexpressing Hoxa9 and Meis1 compared to cells overexpressing Hoxa9 alone. We showed tha
-
While compound had moderate inhibitory
2020-08-05
While compound had moderate inhibitory activity against human CRTH2 receptor, its activity against guinea pig CRTH2 was relatively weak at only one-sixth that in humans. The common use of a guinea pig hyperresponsiveness model to examine antiasthmatic activity in vivo mandated that we enhance inhib
-
br Discussion Taken together our results demonstrate
2020-08-05
Discussion Taken together, our results demonstrate that the changes of striatal dopamine release and locomotor activity observed following chronic nicotine treatment and consequent acute withdrawal are mediated by CRF1, but not CRF2. Previous studies have already indicated that blocking CRF1 woul
-
br Structural and biochemical features of pol X family
2020-08-04
Structural and biochemical features of pol X family polymerases The X-family DNA polymerase (polX) is specialized in DNA repair. This family is composed of four different DNA polymerases: pol β, pol λ, pol μ and TdT. Only three members of the polX family possess an N-terminal BRCT (BRCA1 carboxy-
-
br Genes encoding the DGAT enzymes br
2020-08-04
Genes encoding the DGAT enzymes Membrane topology and structure-function relationships The evolutionary divergence in the gene sequences of the DGAT enzymes is reflected in their predicted protein structures [73]. Through multiple sequence alignment of DGATs, including 59 DGAT1s from 48 organi
-
br DAPK induced pathways It has
2020-08-04
DAPK1 induced pathways It has been for almost twenty years an unsettling debate whether DAPK1 is a pro- or anti-apoptotic kinase. Multiple studies have shown the involvement of DAPK1 in multiple processes of cell growth like endopeptidase check points (Gade et al., 2016), apoptosis, and autophagy
-
br Discussion Our present data show
2020-08-04
Discussion Our present data show that neuroleptics can affect CYP3A via a direct interaction with the enzyme and a significant indirect mechanism (enzyme regulation) produced in vivo. The obtained results revealed interactions of the neuroleptics (added in vitro to control liver microsomes, Model
-
CRTH and the D prostanoid receptor DP function as receptors
2020-08-04
CRTH2 and the D prostanoid receptor (DP1) function as receptors for PGD2[11]. In the central nervous system, DP1 but not CRTH2 is involved in PGE2-induced allodynia, the sleep–wake cycle, glutamate-induced neuronal toxicity, and food intake [12], [13], [14], [15], suggesting that DP1 and CRTH2 have
-
We generate six versions for
2020-08-04
We generate six versions for each benchmark, which are: Table 1 shows the comparison results of the time and memory overhead for each version of benchmark. Note that LB Agar Miller the results of MM and FFT hardened by CFCSS are much lower than the results in the original paper because the ADuC841
-
Endothelin ET is a regulatory neuropeptide with
2020-08-04
Endothelin (ET-1) is a regulatory neuropeptide with widespread distribution in the central nervous system (CNS). ET-1 is produced by endothelial cells in the a83 01 and non endothelial cells such as neurons, astrocytes, and glial cells [24]. ET receptors are found in the brain (cerebral cortex, hip
-
br Conclusions Women who experience POF are
2020-08-04
Conclusions Women who experience POF are at increased risk for cardiovascular morbidity and mortality 8, 9, 10, 11, 12, 13. Impairment of vascular endothelial function is an early marker of atherosclerosis [4]. POF has been associated with significant endothelial dysfunction, which is restored fo
-
A number of chemical strategies have been developed
2020-08-04
A number of chemical strategies have been developed to design activatable optical imaging probes and have been summarized in several excellent reviews 11., 12., 13., 14., 15.. Fluorogenic enzyme substrates are one of the most explored activatable probe types for enzyme detection. These probes contai
-
br Does Selectivity Matter in
2020-08-04
Does Selectivity Matter in Chronic Kidney Disease? Blocking ETB clearly results in a significant increase in circulating plasma ET-1 levels. However, with a mixed antagonist, this increase is unlikely to be important because the vasoconstrictor ETA also is blocked. Side effects including headache
15432 records 760/1029 page Previous Next First page 上5页 756757758759760 下5页 Last page