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br Biological roles of DGK br Summary and future
2020-08-08
Biological roles of DGKϵ Summary and future perspectives The most Octopamine HCl synthesis segment of DGKϵ, comprised of residues 20–42, appears to have no role in binding the lipid substrate DAG or in the acyl chain specificity of substrate phosphorylation. Nevertheless, the sequence in this
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ONO is a potent selective EP
2020-08-08
ONO-8539 is a potent, selective EP1 receptor antagonist that was effective for decreasing ATP induced detrusor overactivity in monkeys, including reductions in nonvoiding contractions and voiding duration, and for increasing the uroflow rate. ONO-8539 also did not affect salivation in rats (Okada, u
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The termini of the substrate recognition and catalytic
2020-08-08
The termini of the substrate recognition and catalytic modules are anchored to opposite sides of the scaffold so that they face each other. Within the substrate recognition module, the coactivators CDC20 and CDH1 have three domains: intrinsically disordered N- and C-terminal regions containing so-ca
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NHEJ does not require sequence homology between the DNA ends
2020-08-07
NHEJ does not require sequence homology between the DNA ends as a prerequisite for ligation. As a result, this process can be error prone while HR is generally considered to be an error-free process. However, how a cell chooses whether to repair a DSB through NHEJ or HR, and how DNA-PK is activated
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Like compound substitution on compound contains amino and ca
2020-08-07
Like compound substitution on compound () contains amino and carboxamide groups attached to adjacent ring positions. These groups have similar interactions as compound with the protein backbone and Glu114. The triazole core is coordinated with Lys291. The triazole ring core π-stacks with Tyr226.
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Eph receptors are overexpressed in
2020-08-06
Eph receptors are overexpressed in various tumor types, suggesting a role of the Eph receptors in tumor progression [12]. Up-regulation of EphrinB2 has been reported in melanomas. In the present investigation, we found that staining intensities of EphrinB2 in arterial and EphB4 in venous endothelium
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br PGE is a major
2020-08-06
PGE is a major contributor to exaggerated pain sensitivity during inflammation. Its production requires the activity of at least one of the two cyclooxygenase (COX) isoforms, constitutively expressed COX-1 or inducible COX-2, with COX-2 being particularly relevant for inflammation-induced PGE form
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On the other hand the interaction
2020-08-06
On the other hand, the interaction of the Kaempferia parviflora extract with CYP3A was uncompetitive with a low Vmax value. In the in vivo study, the Kaempferia parviflora extract did not interfere with CYP3A activity throughout the entire duration of treatment. This is fortunate as CYP3A isoforms
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br Methods br Results br Discussion
2020-08-06
Methods Results Discussion Reduced memory capacity is a core cognitive symptom of schizophrenia [2,[4], [5], [6], [7], [8],[11], [12], [13], [14], [15], [16], [17], [18], [19]] and an early marker of ageing-associated cognitive decline [17]. In this study, using a pharmacological approach,
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br Discussion This study is
2020-08-06
Discussion This study is the first analysis of the transcriptome of drought-stressed soybean crown nodules. Previously, only the transcriptome of developing non-stressed crown nodules has been investigated (van Wyk et al., 2014). In our study drought stress decreased soybean plant growth but resu
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This study also found that CuE
2020-08-06
This study also found that CuE significantly inhibited P-gp activity with no effect on its expression. Since CuE presented potent inhibition on both CYP3A and P-gp activities in vitro, it may increase the exposed quantity of co-administered drugs in the body and cause drug-induced toxicity. To clari
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br Significance Preclinical data indicate that
2020-08-06
Significance Preclinical data indicate that tumor-associated macrophages (TAMs) represent an attractive therapeutic target as they represent key orchestrators of various tumor-promoting processes, such as escape of immune surveillance. Here, we report that treatment with an anti-CSF-1R antibody (
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In reviewing the literature it is apparent that
2020-08-06
In reviewing the literature, it is apparent that three major methodological approaches are used to evaluate the behavioral effects induced by targeted 5416 alterations. These methods include knockout procedures, antisense oligonucleotide strategies, and administration of specific CRF receptor antag
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We have also shown that knockdown of the
2020-08-06
We have also shown that knockdown of the SR protein 9G8 in the larval fat body also leads to a decreased triglyceride storage phenotype. Surprisingly, the knockdown of 9G8 in the adult female fat body resulted in a large increase in triglyceride levels and this is mainly due to an increase in the am
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The characteristics and consistencies of sputum that
2020-08-06
The characteristics and consistencies of sputum that have been adjudged to be a non-invasive alternative to bronchoscopy and BAL in the diagnosis of respiratory infections were studied in this audit. The sputum classification adopted by the MRCM was easier to assess and evaluate than the previous Ge
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