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We have compared the potency of a series of DNA
2020-09-09
We have compared the potency of a series of DNA-directed alkylating agents, including N-mustard-acridine, N-mustard-quinoline, and N-mustard-quinazoline conjugates previously synthesized in our laboratory [7], [13], and currently used drugs (oxaliplatin, cisplatin, or 5-FU) for the treatment of CRC
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br Conclusions br Acknowledgements br Introduction Liver can
2020-09-09
Conclusions Acknowledgements Introduction Liver cancer was the fifth most common cancer and the second leading cause of cancer-related death worldwide [1]. Most of primary liver cancers (70–90%) occurring worldwide are hepatocellular carcinoma (HCC) [2]. Persistent hepatitis B virus (HBV) i
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br Methods br Results The characteristics of the control sub
2020-09-09
Methods Results The characteristics of the 20 control subjects and 63 patients stratified by SDB severity, matched for age, sex, and BMI z-score, are described in Table 1. As expected, AHI, OAI, ODI, and SLT90% increased and SpO2 decreased progressively with the severity of the disease. Dis
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br Materials and methods br Results The i
2020-09-09
Materials and methods Results The i.v. administration of urocortin 2 reduced the mean arterial blood pressure in a dose-dependent manner (Fig. 1). The ED50 for the urocortin 2 cumulative dose–response effect on mean arterial blood pressure was 0.014±0.004 mg kg−1. Urocortin 2 administration ha
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In general accurate results for the prediction of
2020-09-09
In general, accurate results for the prediction of the solubility in scCO2 + cosolvents using the CPA-EoS were verified. ALD values for each solute (Table 1) varied from 0.04 to 1.5. Few solutes, such as lauric acid, myristic acid, hydroquinone and salicylic acid, presented the highest ALD values. A
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Our conclusion is in disagreement with
2020-09-09
Our conclusion is in disagreement with that of a recent paper by Park et al. [10], which suggests that nitric oxide (NO) inhibition of VHL recruitment occurs by nitrosylation of the 520 cysteine in HIF-1α, and that SNAP does not directly inhibit hydroxylation of HIF peptide by HPH-2. Although this d
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Our data supports the conclusion that the
2020-09-08
Our data supports the conclusion that the exonuclease activity thought to be intrinsic to Artemis is not a component of the Artemis polypeptide. Many possibilities exist to explain the presence of the exonuclease activity in less-pure fractions of Artemis. It is possible that the exonuclease is simp
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The folate pathway plays an essential
2020-09-08
The folate pathway plays an essential role in cell survival by generating 5, 10-methylene tetrahydrofolate as a one-carbon donor for the synthesis of deoxythymidine monophosphate (dTMP), purines, methionine and histidine. Disruption of this pathway leads to the critical deficiency of these key molec
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Given the excellent in vitro pharmacology profiles
2020-09-08
Given the excellent in vitro pharmacology profiles of methyl ester 28 and primary amide 29 efforts were reengaged on neutral analogs of these leads, with a focus on non-amide replacements for the carboxylic Penciclovir Sodium australia functionality of 1. Acetonitrile 49 was found to have a good ba
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Form the previous literature It
2020-09-08
Form the previous literature, It was observed that RHA was burnt in the range of 500 °C to 700 °C, with high content of quartzite silica was used is a partial replacement of cement in mortar and in concrete. The results shown an excellent behavior in enhancing the mechanical properties of cement mor
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However in many of the above mentioned studies the
2020-09-08
However, in many of the above mentioned studies, the NaCl concentrations in the extraction buffers were different from those used here. For instance, in the study that performed cathepsin D extraction from human AD PRT 4165 tissue, the concentration was 150mM [30], while that for the extraction of
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Our module is designed to allow in process measurement
2020-09-07
Our module is designed to allow in-process measurement of [C]-tracer molar activity (MA, GBq/μmol at EOB) using a phenethyl detector with a UV detector at the outlet of the HPLC-portion of the system. In the HPLC chromatogram, peak analysis of the chromatographic data utilized PeakSimple software (S
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A more refined picture of cholinesterase activity patterns m
2020-09-07
A more refined picture of cholinesterase activity patterns may be obtained by measuring ChE activity of the same sample before and after addition of certain cholinesterase inhibitors, with differential specificity for different components of total ChE activity, such as BW284c51 (BW1,5-bis-(4-allyldi
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SCH 58261 Materials and methods Construction of the Chk YB
2020-09-07
Materials and methods Construction of the Chk-YB-1b-Neo vector. Approximately 107 plaques from a chicken genomic library established in EMBL3 vector (Clontech Palo Alto, CA) was screened and one clone containing a 12kb insert was selected. Digestion of this clone with SalI and EcoRI restriction enz
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Fmoc-Phe-OH receptor Over the last decade numerous
2020-09-07
Over the last decade, numerous studies have evaluated the acute, short-term, and medium-term impact of pulmonary vasodilators on Fontan physiology.23., 24., 25., 26., 27., 28., 29., 30., 31. Although different Fmoc-Phe-OH receptor of medications have been evaluated, phosphodiesterase-5 (PDE-5) inhi
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