• That DGAT mediated hepatic steatosis did not

  2021-05-31

  

  That DGAT-mediated hepatic steatosis did not lead to insulin resistance was clearly demonstrated in Liv-DGAT2-low mice by their normal blood glucose and plasma insulin levels, normal glucose and insulin tolerance, normal insulin sensitivity by hyperinsulinemic-euglycemic clamp studies, and normal he

• Functional studies suggested the presence of a

  2021-05-31

  

  Functional studies suggested the presence of a cysLT1 receptor. We observed an LTD4-induced cytosolic calcium response, albeit one that was very weak by most standards. The magnitude of the average response was partially explained by the low percentage of YK-4-279 showing a very transient response.

• Fusion genes are formed as the result of either structural

  2021-05-28

  

  Fusion genes are formed as the result of either structural chromosomal rearrangement including, primarily, translocation, inversion, amplification and deletion, or non-structural aberrations caused by cis- and trans-splicing or transcriptional read-through. Such events are known to play important ro

• Dynasore Results are expressed as mean s e m

  2021-05-28

  

  Results are expressed as mean±s.e.m. Paired or unpaired Student's t test was used for comparisons between 2 groups and one-way ANOVA followed by Bonferroni's post-test for more groups. Statistical significance was assigned if p Results and discussion Variations in [Ca2+]i in cardiomyocytes loaded

• Molecular docking study of compound was performed using the

  2021-05-28

  

  Molecular docking study of FHPI was performed using the Schrödinger Small-Molecule Drug Discovery Suite taking advantage of known X-ray crystal structures of activated EPAC2 protein. The model shows that compound occupies the CBD of EPAC2 and forms hydrogen bonds with Arg448 and the cyano-hydrazi

• To develop antagonists selective for

  2021-05-28

  

  To develop antagonists selective for the mouse EP1 receptor, we started with compound (), synthesized as previously described (). Diethyl dipicolinic UNC0638 () was reduced with NaBH to . Parikh–Doering oxidation of with sulfur trioxide–pyridine complex and DMSO produced the unstable aldehyde . 4-Ch

• br Discussion Nowadays data of uncommon EGFR mutations are l

  2021-05-28

  

  Discussion Nowadays, data of uncommon EGFR mutations are limited, considering that patients carrying these rare alterations are usually excluded from clinical trials. Available survival data of activity of EGFR TKIs on this class of mutations, coming from a small number of usually retrospective s

• Regardless of its effect on EBV

  2021-05-28

  

  Regardless of its effect on EBV infection, the chemokine system has been found to be regulated in both nasopharyngeal cancer and Hodgkin lymphoma. As such, Hodgkin and Reed–Sternberg (HRS) cells from Hodgkin lymphoma and nasopharyngeal carcinoma cells have been shown to express CXCL8 and CCL17. Furt

• Circulating NK subsets also show considerable differences in

  2021-05-28

  

  Circulating NK subsets also show considerable differences in homing molecules. CD56bright (Z)-4-Hydroxytamoxifen express the chemokine receptor CCR7 and L-selectin, which drive their migration to secondary lymphoid organs (Fehniger et al., 2003). In contrast, CD56dim display a high density of CX3CR

• Likewise the conserved cysteine in

  2021-05-28

  

  Likewise, the conserved cysteine in the E2 protein is the only residue shown to be essential for the transfer of Ub/Ubl from E2 to the HECT ligases (Dye and Schulman, 2007, Wu et al., 2003). However, all other terminal Ub/Ubl transfer reactions involving E2 enzymes suggest a critical role for the ta

• Programmed cellular death or apoptosis is a process genetica

  2021-05-28

  

  Programmed cellular death or apoptosis is a process genetically controlled that plays an important role in cellular homeostasis, being an important defense mechanism to remove cells that have been infected, damaged or mutated (Smith and Smith, 2012, Wlodkowic et al., 2011). Nevertheless, apoptosis s

• Consistent with the known tolerance of the Suzuki

  2021-05-28

  

  Consistent with the known tolerance of the Suzuki–Miyaura reaction to a wide range of aryl substituents, we subsequently found that the commercially available 3-hydroxyphenylboronic carboxypeptidase pinacol ester () could be coupled to , to give directly and in comparable yield. Smooth conversion

• br Use of recombinant collagen to study DDR collagen

  2021-05-28

  

  Use of recombinant collagen to study DDR–collagen interactions Synthetic peptides have proven highly valuable in replicating the characteristics of collagen and in defining the sites on collagen essential for binding and studying protein–collagen interactions. There are, however, disadvantages to

• Gene amplification PCR amplifications were

  2021-05-28

  

  Gene amplification. PCR amplifications were performed using genomic DNA from the different organisms studied as template and two degenerate oligonucleotides (PP1 and PP2) as primersPP1 corresponded to the sense codons of the amino azd2014 motif AGGI(A/S)EM, and PP2 to the antisense sequence of the

• We have previously reported the

  2021-05-27

  

  We have previously reported the characterization of A-127722, a novel, non-peptide endothelin antagonist that displays very high affinity binding (K=69 pM) with a more than 1000-fold greater affinity for human endothelin ETA than ETB receptor. Although A-127722 is >1000-fold more selective for endot

16373 records 661/1092 page Previous Next First page 上5页 661662663664665 下5页 Last page