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Furthermore it is important to point out that
2018-10-23
Furthermore, it Go 6976 is important to point out that, in model 4 the elasticity for unlisted and non-large firms, evaluated at sample mean, is 0.66, i.e., the impact of 1.0% in cash flow implies an increase of 0.66% in investment, similar to the elasticity of small firms groups in regressions of
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We have shown that the gatekeeper valine to methionine
2018-10-23
We have shown that the gatekeeper valine to methionine substitutions in FGFR1 and FGFR3 resulted in reduction of sensitivity to selective inhibitors PD17307 and AZD4547; two other tested inhibitors, AP24534 and TKI258, retained their efficacy (Figs. 1, 2 and 4, Table 1). While the multi-kinase, type
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A key finding of our study is the demonstration
2018-10-23
A key finding of our study is the demonstration that exposure to HG leads to a rapid increase in mesangial cell MtDNA, accompanied by unchanging/decreased transcription of mitochondrial encoded mRNAs and little change in nuclear encoded mitochondrial mRNAs in renal cells. The amount of MtDNA is know
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br Materials and Methods br Results br Discussion In sum
2018-10-23
Materials and Methods Results Discussion In sum, we found that a ‘melanoma-related’ panel of miRNAs was expressed in metastatic melanoma in a stage-specific manner and, together with the tissue pathology and nodal status, was prognostic for recurrence and OS. These markers may therefore als
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We chose to study mAb because
2018-10-23
We chose to study mAb41 because it is a potent neutralizing antibody that arises from an antigenic region that can induce both neutralizing and non-neutralizing antibodies, providing a basis for investigating whether mAb41 mimotopes could induce immune responses with mAb41-like properties, including
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This hypothesis also provides some insight into more
2018-10-23
This p38 inhibitor also provides some insight into more pronounced beneficial effects of low alcohol consumption on the risk of AP in women compared to men. Specifically, women are more likely to develop biliary problems and gallstones (Shen et al., 2013; Russell et al., 1998) and therefore constit
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In this editorial of the first
2018-10-23
In this editorial of the first anniversary issue of , we cannot help but reflect on aging. Tremendous biomedical successes over the last century have contributed to ever-increasing life expectancies. In its September 30, 2015 , the World Health Organization estimates that the global average life exp
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br Treatment decisions are generally based on MPN
2018-10-23
Treatment decisions are generally based on MPN subtype, risk category, age, and disease manifestations. For PV and ET, thrombosis risk category often guides the decision to use cytoreductive and anti-platelet therapies (and phlebotomy for PV). Historically, treatment of MF has been guided by the p
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br Size Stability and Toxicity A substantial
2018-10-23
Size, Stability, and Toxicity A substantial number of investigations aiming to unravel the mechanism of the disease have accepted an intermediate structure of aggregated Aβ which is formed earlier than plaques and has been linked to the pathogenesis (Kayed and Lasagna-Reeves, 2013; Klein, 2013; H
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To calculate the intensity and duration of dengue transmissi
2018-10-23
To calculate the intensity and duration of dengue transmission, a seasonality curve was generated by plotting the decadally averaged VC as a function of month for each of the 10 cities first and then for each decade over the two centuries. The intensity of DEP was estimated by averaging the VC over
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The strong negative association between IgG and IgM levels
2018-10-23
The strong negative association between IgG and IgM levels and CHD events needs to be considered in the context of other biomarkers that have been evaluated as adjuncts to traditional risk assessments. Although the ASCOT-CRP substudy concluded that measuring CRP had little utility in refining CV ris
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A potential limitation of our study was
2018-10-23
A potential limitation of our study was the use of hospital controls as proxies of healthy people. Controls were admitted for a wide variety of routine conditions unrelated to tobacco and it is implausible that a high proportion of the controls with a detectable damaging TP53 mutation developed a ca
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trpv1 antagonist Like other natural history cohorts rapid di
2018-10-23
Like other natural history cohorts, rapid disease progression was observed at a 7–9% frequency regardless of HIV-1 subtype but slow progressors/controllers appeared only in subtype A and C infections. The differential rates of CD4 T-cell declines (D>A>C) was still significant when rapid progressors
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IL induces STAT activation in myeloid
2018-10-23
IL-10 induces STAT3 activation in myeloid Z-VDVAD-FMK manufacturer resulting in the regulation of proinflammatory gene expression in these cells, and myeloid cell specific deletion of STAT3 develop colitis in a phenomena similar to IL-10 deficient mice (Kobayashi et al., 2003), suggesting that STAT
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IL induces STAT activation in myeloid
2018-10-23
IL-10 induces STAT3 activation in myeloid serine protease resulting in the regulation of proinflammatory gene expression in these cells, and myeloid cell specific deletion of STAT3 develop colitis in a phenomena similar to IL-10 deficient mice (Kobayashi et al., 2003), suggesting that STAT3 is key i
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