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br Results br Discussion Here
2018-10-24
Results Discussion Here, we describe the identification of an epigenetic mechanism necessary and sufficient to maintain pluripotency and/or avoid precocious differentiation of the germ cell lineage in C. elegans. Histone H3K4 demethylase SPR-5/LDS1 physically interacts with the LET-418-contain
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A link between PARK and mitochondrial biology was
2018-10-24
A link between PARK2 and mitochondrial biology was first established in Drosophila, which displayed impairment in mitochondrial function and neuronal loss in an age-dependent manner when rendered deficient for PARK2 (Greene et al., 2003). Likewise, similar mitochondrial defects exhibited in Park2 kn
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Herein we describe increased VEGFA and SEMA
2018-10-24
Herein, we describe increased VEGFA and SEMA3A expression in bone marrow mitoxantrone from de novo AML patients and the possible dominant effect of SEMA3A, suggesting that SEMA3A could control the effects caused by VEGFA. However, some questions remain: Why is SEMA3A expression increased in BMSCs fr
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Understanding http www apexbt com media diy images wb
2018-10-24
Understanding the regulatory pathways that control the establishment of the different hematopoietic programs and developing methods to identify and isolate progenitors for each are essential to accurately model hematopoiesis in ESC and induced PSC differentiation cultures and ultimately to generate
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Previous reports have shown that
2018-10-24
Previous reports have shown that inhibition of GSK3 by CHIR promotes mESC self-renewal through activation of Wnt/β-catenin signaling pathway (Martello et al., 2012). In the absence of Wnt ligand or CHIR, T cell factor 3 (TCF3) occupies the promoter regions of many pluripotency genes (e.g., Nanog, Es
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Aminoallyl-dUTP - Cy3 Here we study the impact of the common
2018-10-24
Here we study the impact of the common GBA-N370S mutation on the phenotype of patient-specific dopaminergic neuronal cultures differentiated from iPSC lines derived from patients with PD and identify deficits in protein homeostasis. Our results suggest that the heterozygous GBA-N370S mutation leads
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To address whether the bivalent state requires miRNAs or oth
2018-10-24
To address whether the bivalent state requires miRNAs or other Dicer-dependent functions, we reconstituted Dicer-deficient ESCs with miR-294, a member of the miR-290–295 miRNA family. ChIP-PCR showed that EZH2 binding was restored 48 hr later at the Gata3, Pax6, and Nr2f2 promoters (Figure 4B). Thus
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ack1 inhibitor Enhancers play a central role
2018-10-24
Enhancers play a central role in cell-type-specific and stage-specific regulation of gene expression and are capable of acting over a distance ranging from several to hundreds, and in rare cases even thousands of kilobases from their target genes (Bulger and Groudine, 2011; Ong and Corces, 2011, 201
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br Results br Discussion The transplant created chimera enab
2018-10-24
Results Discussion The transplant-created chimera enables us to investigate the effects of human neural order UO 126 in the adult mouse spinal cord (Chen et al., 2015). Using this model, we have shown that neural cells from sALS patient iPSCs, especially astrocytes, integrate into the mouse s
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When the parameter is close
2018-10-24
When the parameter μ is close to zero, we will have: From here it follows that in the case of a low relative hardness of the composite, the SIF limit values are expressed by formulae (29) for a homogeneous wedge at . Notice that asymptotes (31) and (32) can also be obtained by solving the limitin
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It is important for sorption enhanced catalytic processes oc
2018-10-24
It is important for sorption-enhanced catalytic processes occurring in an aqueous medium that the MnО2 phase be in a hydrated state. This requirement imposes certain restrictions on the conditions in which this phase can be synthesized, particularly on the CL surface that is sensitive to acidic and
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Table shows results from models partitioned
2018-10-24
Table 4 shows results from models partitioned by sex. In ci-1033 to the pooled results, Model 2 of Table 4, our fully adjusted model, shows no statistically significant difference in the probability of being a current smoker among the first generation males in the sample by age at migration. This t
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Second due in large part to data limitations few studies
2018-10-24
Second, due in large part to data limitations, few studies have investigated ancestral health disparities among second-generation black immigrants, which conceals the increasing heterogeneity of the second-generation black immigrant population. Immigrants from the Caribbean have historically compris
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br Acknowledgements This work was
2018-10-24
Acknowledgements This work was supported by NIH grants 1R01MD006064 and 1R21HD066312 (Dr. Osypuk, PI), and the Minnesota Population Center grant P2C HD041023. Funders did not have any role in design or conduct of the study; collection, management, analysis, and interpretation of the data; or prep
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Thus when these two factors
2018-10-24
Thus, when these two factors, spokesperson gender and pitch, are considered together, the effect is expected to be multiplied; that is, a low-pitched male voice is expected to be the most effective combination in achieving a positive response. Furthermore, we propose this hypothesis: Individual dif
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